6h0w: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6h0w is ~~ON HOLD~~

==Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035==

== Structural highlights ==

<table><tr><td colspan='2'>[[6h0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0W OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6H0W FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.23Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FHW:(2~{R})-3-phenyl-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide'>FHW</scene>, <scene name='pdbligand=I1L:[2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoylamino]azanium'>I1L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6h0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0w OCA], [https://pdbe.org/6h0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6h0w RCSB], [https://www.ebi.ac.uk/pdbsum/6h0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0w ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>

~~Authors~~:

==See Also==

*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]

~~Description~~:

== References ==

[[Category: ~~Unreleased Structures~~]]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Heinemann U]]

[[Category: Link A]]

[[Category: Malecki PH]]

[[Category: Weiss MS]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6h0w is ON HOLD
+==Crystal Structure of KDM4D with tetrazolylhydrazide ligand NS035==
+<StructureSection load='6h0w' size='340' side='right'caption='[[6h0w]], [[Resolution|resolution]] 1.23&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6H0W FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.23&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FHW:(2~{R})-3-phenyl-2-(2~{H}-1,2,3,4-tetrazol-5-yl)propanehydrazide'>FHW</scene>, <scene name='pdbligand=I1L:[2-(2~{H}-1,2,3,4-tetrazol-5-yl)ethanoylamino]azanium'>I1L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6h0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0w OCA], [https://pdbe.org/6h0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6h0w RCSB], [https://www.ebi.ac.uk/pdbsum/6h0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM4D_HUMAN KDM4D_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
-Authors:
+==See Also==
+*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Heinemann U]]
+[[Category: Link A]]
+[[Category: Malecki PH]]
+[[Category: Weiss MS]]