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| ==CryoEM structure of the full virion of a human rhinovirus C== | | ==CryoEM structure of the full virion of a human rhinovirus C== |
| <StructureSection load='5k0u' size='340' side='right' caption='[[5k0u]], [[Resolution|resolution]] 2.79Å' scene=''> | | <SX load='5k0u' size='340' side='right' viewer='molstar' caption='[[5k0u]], [[Resolution|resolution]] 2.79Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[5k0u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_c Human rhinovirus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K0U FirstGlance]. <br> | | <table><tr><td colspan='2'>[[5k0u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhinovirus_C Rhinovirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K0U FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jzg|5jzg]]</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.79Å</td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0u OCA], [http://pdbe.org/5k0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k0u RCSB], [http://www.ebi.ac.uk/pdbsum/5k0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0u ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0u OCA], [https://pdbe.org/5k0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k0u RCSB], [https://www.ebi.ac.uk/pdbsum/5k0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0u ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/E5D8F2_9ENTO E5D8F2_9ENTO] |
| Isolates of rhinovirus C (RV-C), a recently identified Enterovirus (EV) species, are the causative agents of severe respiratory infections among children and are linked to childhood asthma exacerbations. The RV-C have been refractory to structure determination because they are difficult to propagate in vitro. Here, we report the cryo-EM atomic structures of the full virion and native empty particle (NEP) of RV-C15a. The virus has 60 "fingers" on the virus outer surface that probably function as dominant immunogens. Because the NEPs also display these fingers, they may have utility as vaccine candidates. A sequence-conserved surface depression adjacent to each finger forms a likely binding site for the sialic acid on its receptor. The RV-C, unlike other EVs, are resistant to capsid-binding antiviral compounds because the hydrophobic pocket in VP1 is filled with multiple bulky residues. These results define potential molecular determinants for designing antiviral therapeutics and vaccines.
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| Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.,Liu Y, Hill MG, Klose T, Chen Z, Watters K, Bochkov YA, Jiang W, Palmenberg AC, Rossmann MG Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8997-9002. doi:, 10.1073/pnas.1606595113. Epub 2016 Jul 11. PMID:27511920<ref>PMID:27511920</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 5k0u" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </SX> |
| [[Category: Human rhinovirus c]] | | [[Category: Large Structures]] |
| [[Category: Chen, Z]] | | [[Category: Rhinovirus C]] |
| [[Category: Hill, M G]] | | [[Category: Chen Z]] |
| [[Category: Jiang, W]] | | [[Category: Hill MG]] |
| [[Category: Klose, T]] | | [[Category: Jiang W]] |
| [[Category: Liu, Y]] | | [[Category: Klose T]] |
| [[Category: Palmenberg, A C]] | | [[Category: Liu Y]] |
| [[Category: Rossmann, M G]] | | [[Category: Palmenberg AC]] |
| [[Category: Watters, K E]] | | [[Category: Rossmann MG]] |
| [[Category: Jelly roll]]
| | [[Category: Watters KE]] |
| [[Category: Virus]]
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