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[[Image:2oad.gif|left|200px]]


{{Structure
==Structure of Glutathione-S-Transferase C169A Mutant==
|PDB= 2oad |SIZE=350|CAPTION= <scene name='initialview01'>2oad</scene>, resolution 2.500&Aring;
<StructureSection load='2oad' size='340' side='right'caption='[[2oad]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GTB:S-(P-NITROBENZYL)GLUTATHIONE'>GTB</scene>
<table><tr><td colspan='2'>[[2oad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAD FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE= Gstp1, Gstpib ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTB:S-(P-NITROBENZYL)GLUTATHIONE'>GTB</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oad OCA], [https://pdbe.org/2oad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oad RCSB], [https://www.ebi.ac.uk/pdbsum/2oad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oad ProSAT]</span></td></tr>
|RELATEDENTRY=[[2oa7|2OA7]], [[2oac|2OAC]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oad OCA], [http://www.ebi.ac.uk/pdbsum/2oad PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oad RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/GSTP1_MOUSE GSTP1_MOUSE] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oad_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oad ConSurf].
<div style="clear:both"></div>


'''Structure of Glutathione-S-Transferase C169A Mutant'''
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2OAD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAD OCA].
[[Category: Large Structures]]
[[Category: Glutathione transferase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Khan AR]]
[[Category: Khan, A R.]]
[[Category: Kyrieleis OJ]]
[[Category: Kyrieleis, O J.]]
[[Category: Mantle TJ]]
[[Category: Mantle, T J.]]
[[Category: McManus G]]
[[Category: McManus, G.]]
[[Category: enzyme and ligand complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:14:58 2008''

Latest revision as of 10:33, 30 August 2023

Structure of Glutathione-S-Transferase C169A Mutant

2oad, resolution 2.50Å

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