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[[Image:2oby.gif|left|200px]]


{{Structure
==Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)==
|PDB= 2oby |SIZE=350|CAPTION= <scene name='initialview01'>2oby</scene>, resolution 3.00&Aring;
<StructureSection load='2oby' size='340' side='right'caption='[[2oby]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
<table><tr><td colspan='2'>[[2oby]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBY FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE= TP53I3, PIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oby OCA], [https://pdbe.org/2oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oby RCSB], [https://www.ebi.ac.uk/pdbsum/2oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oby ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oby OCA], [http://www.ebi.ac.uk/pdbsum/2oby PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oby RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/QORX_HUMAN QORX_HUMAN] May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).<ref>PMID:19349281</ref>
 
== Evolutionary Conservation ==
'''Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2oby_consurf.spt"</scriptWhenChecked>
2OBY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBY OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oby ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Debreczeni, J.]]
[[Category: Debreczeni J]]
[[Category: Delft, F Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Farres J]]
[[Category: Farres, J.]]
[[Category: Fita I]]
[[Category: Fita, I.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Haroniti A]]
[[Category: Haroniti, A.]]
[[Category: Johansson C]]
[[Category: Johansson, C.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Pares X]]
[[Category: Pares, X.]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W.]]
[[Category: Porte S]]
[[Category: Porte, S.]]
[[Category: Shafqat N]]
[[Category: Shafqat, N.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Valencia E]]
[[Category: Valencia, E.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:15:35 2008''

Latest revision as of 10:34, 30 August 2023

Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)

2oby, resolution 3.00Å

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