2l3n: Difference between revisions
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==Solution structure of Rap1-Taz1 fusion protein== | ==Solution structure of Rap1-Taz1 fusion protein== | ||
<StructureSection load='2l3n' size='340' side='right' caption='[[2l3n | <StructureSection load='2l3n' size='340' side='right'caption='[[2l3n]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2l3n]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2l3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3N FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3n OCA], [https://pdbe.org/2l3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3n RCSB], [https://www.ebi.ac.uk/pdbsum/2l3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/TAZ1_SCHPO TAZ1_SCHPO] Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere-replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.[https://www.uniprot.org/uniprot/RAP1_SCHPO RAP1_SCHPO] Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE). Unlike yeast, exhibits no effect in transcription regulation.<ref>PMID:11676924</ref> <ref>PMID:11676925</ref> <ref>PMID:19948484</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Schizosaccharomyces pombe 972h-]] | ||
[[Category: Hu | [[Category: Chen Y]] | ||
[[Category: Lei | [[Category: Hu H]] | ||
[[Category: Wang | [[Category: Lei M]] | ||
[[Category: Zhou | [[Category: Wang F]] | ||
[[Category: Zhou ZR]] | |||
Latest revision as of 06:52, 1 May 2024
Solution structure of Rap1-Taz1 fusion protein
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