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[[Image:2of1.jpg|left|200px]]


{{Structure
==Cryogenic crystal structure of the Staphylococcal Nuclease variant truncated Delta+PHS I92W==
|PDB= 2of1 |SIZE=350|CAPTION= <scene name='initialview01'>2of1</scene>, resolution 1.92&Aring;
<StructureSection load='2of1' size='340' side='right'caption='[[2of1]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Residue+A+502'>AC1</scene>, <scene name='pdbsite=AC2:Dms+Binding+Site+For+Residue+A+403'>AC2</scene> and <scene name='pdbsite=AC3:Thp+Binding+Site+For+Residue+A+501'>AC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=THP:THYMIDINE-3&#39;,5&#39;-DIPHOSPHATE'>THP</scene>
<table><tr><td colspan='2'>[[2of1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OF1 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Micrococcal_nuclease Micrococcal nuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.31.1 3.1.31.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
|GENE= nuc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=THP:THYMIDINE-3,5-DIPHOSPHATE'>THP</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00175 SNc]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2of1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of1 OCA], [https://pdbe.org/2of1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2of1 RCSB], [https://www.ebi.ac.uk/pdbsum/2of1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2of1 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1tqo|1TQO]], [[1tr5|1TR5]], [[1tt2|1TT2]], [[2oeo|2OEO]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2of1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2of1 OCA], [http://www.ebi.ac.uk/pdbsum/2of1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2of1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NUC_STAAU NUC_STAAU] Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/2of1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2of1 ConSurf].
<div style="clear:both"></div>


'''Cryogenic crystal structure of the Staphylococcal Nuclease variant truncated Delta+PHS I92W'''
==See Also==
 
*[[Staphylococcal nuclease 3D structures|Staphylococcal nuclease 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2OF1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OF1 OCA].
[[Category: Large Structures]]
[[Category: Micrococcal nuclease]]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Gittis, A G.]]
[[Category: Gittis AG]]
[[Category: Reynald, R L.]]
[[Category: Reynald RL]]
[[Category: hydrolase]]
[[Category: ob-fold]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:16:49 2008''
Retrieved from "https://proteopedia.org/2of1"