6e7w: Difference between revisions

(3 intermediate revisions by the same user not shown)

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6e7w is ~~ON HOLD until Paper Publication~~

==Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-115==

== Structural highlights ==

<table><tr><td colspan='2'>[[6e7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7W OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6E7W FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXM:~{N}-[4-[(2~{S})-3-[2-(3,4-dichlorophenyl)ethyl-propan-2-yl-amino]-2-oxidanyl-propoxy]phenyl]methanesulfonamide'>HXM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6e7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7w OCA], [https://pdbe.org/6e7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e7w RCSB], [https://www.ebi.ac.uk/pdbsum/6e7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7w ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).

~~Authors~~:

==See Also==

*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]

~~Description~~:

__TOC__

[[Category: ~~Unreleased Structures~~]]

</StructureSection>

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Xenopus laevis]]

[[Category: Furukawa H]]

[[Category: Regan MC]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6e7w is ON HOLD  until Paper Publication
+==Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-115==
+<StructureSection load='6e7w' size='340' side='right'caption='[[6e7w]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E7W FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HXM:~{N}-[4-[(2~{S})-3-[2-(3,4-dichlorophenyl)ethyl-propan-2-yl-amino]-2-oxidanyl-propoxy]phenyl]methanesulfonamide'>HXM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e7w OCA], [https://pdbe.org/6e7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e7w RCSB], [https://www.ebi.ac.uk/pdbsum/6e7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e7w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
-Authors:
+==See Also==
+*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
-Description:
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Xenopus laevis]]
+[[Category: Furukawa H]]
+[[Category: Regan MC]]