6e94: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: '''Unreleased structure''' The entry 6e94 is ON HOLD Authors: Hudson, N.O., Whitby, F.G., Buck-Koehntop, B.A. Description: Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 6e94 is ON HOLD
==Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R in complex with methylated DNA==
 
<StructureSection load='6e94' size='340' side='right'caption='[[6e94]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
Authors: Hudson, N.O., Whitby, F.G., Buck-Koehntop, B.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6e94]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E94 FirstGlance]. <br>
Description: Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R domain in complex with the methylated DNA binding motif
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.594&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Hudson, N.O]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e94 OCA], [https://pdbe.org/6e94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e94 RCSB], [https://www.ebi.ac.uk/pdbsum/6e94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e94 ProSAT]</span></td></tr>
[[Category: Whitby, F.G]]
</table>
[[Category: Buck-Koehntop, B.A]]
== Function ==
[https://www.uniprot.org/uniprot/ZBT38_HUMAN ZBT38_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).[UniProtKB:Q5EXX3]<ref>PMID:16354688</ref> <ref>PMID:24726359</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Buck-Koehntop BA]]
[[Category: Hudson NO]]
[[Category: Whitby FG]]
Retrieved from "https://proteopedia.org/6e94"