6ea9: Difference between revisions

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New page: '''Unreleased structure''' The entry 6ea9 is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 6ea9 is ON HOLD
==Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']==
 
<StructureSection load='6ea9' size='340' side='right'caption='[[6ea9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ea9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EA9 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9BG:2,5-GpAp'>9BG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ea9 OCA], [https://pdbe.org/6ea9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ea9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ea9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ea9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POXIN_VACCW POXIN_VACCW] Nuclease that is responsible for viral evasion of host cGAS-STING innate immunity (PubMed:30728498). Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF-kappa-B immune responses (PubMed:30728498).<ref>PMID:30728498</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vaccinia virus WR]]
[[Category: Eaglesham JB]]
[[Category: Kranzusch PJ]]
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