6h8t: Difference between revisions
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New page: '''Unreleased structure''' The entry 6h8t is ON HOLD Authors: Cherrier, M.V., Amara, P., Talbi, B., Salmin, M., Fontecilla-Camps, J.C. Description: Crystal structure of Papain modify b... |
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==Crystal structure of Papain modify by achiral Ru(II)complex== | |||
<StructureSection load='6h8t' size='340' side='right'caption='[[6h8t]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6h8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Carica_papaya Carica papaya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6H8T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMX:(BETAR)-BETA-HYDROXY-L-TYROSINE'>OMX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TXY:3-[(5S)-4,5-DIHYDROXYCYCLOHEXA-1,3-DIEN-1-YL]-L-ALANINE'>TXY</scene>, <scene name='pdbligand=YXX:CHLORO(1-{5-[DI(PYRIDIN-2-YL-KAPPAN)AMINO]PENTYL}PYRROLIDINE-2,5-DIONE)RUTHENIUM'>YXX</scene>, <scene name='pdbligand=YXZ:CHLORO[N,N-DI(PYRIDIN-2-YL-KAPPAN)PENTANE-1,5-DIAMINE]RUTHENIUM'>YXZ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6h8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h8t OCA], [https://pdbe.org/6h8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6h8t RCSB], [https://www.ebi.ac.uk/pdbsum/6h8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6h8t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PAPA1_CARPA PAPA1_CARPA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one. | |||
Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.,Cherrier MV, Amara P, Talbi B, Salmain M, Fontecilla-Camps JC Metallomics. 2018 Sep 3. doi: 10.1039/c8mt00160j. PMID:30175357<ref>PMID:30175357</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[ | </div> | ||
[[Category: | <div class="pdbe-citations 6h8t" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: Amara | ==See Also== | ||
[[Category: Cherrier | *[[Papain|Papain]] | ||
[[Category: Fontecilla-Camps | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Carica papaya]] | |||
[[Category: Large Structures]] | |||
[[Category: Amara P]] | |||
[[Category: Cherrier MV]] | |||
[[Category: Fontecilla-Camps JC]] | |||
[[Category: Salmin M]] | |||
[[Category: Talbi B]] | |||
Latest revision as of 06:22, 1 October 2025
Crystal structure of Papain modify by achiral Ru(II)complex
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