2os1: Difference between revisions

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[[Image:2os1.jpg|left|200px]]


{{Structure
==Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes==
|PDB= 2os1 |SIZE=350|CAPTION= <scene name='initialview01'>2os1</scene>, resolution 1.50&Aring;
<StructureSection load='2os1' size='340' side='right'caption='[[2os1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Ni+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+501'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+502'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+A+503'>AC4</scene> and <scene name='pdbsite=AC5:Bb2+Binding+Site+For+Residue+A+400'>AC5</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2os1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS1 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE= def ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os1 OCA], [https://pdbe.org/2os1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os1 RCSB], [https://www.ebi.ac.uk/pdbsum/2os1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os1 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2os0|2OS0]], [[2os3|2OS3]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2os1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os1 OCA], [http://www.ebi.ac.uk/pdbsum/2os1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2os1 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DEF_ENTFA DEF_ENTFA] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
 
== Evolutionary Conservation ==
'''Structures of actinonin bound peptide deformylases from E. faecalis and S. pyogenes'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os1_consurf.spt"</scriptWhenChecked>
2OS1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS1 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os1 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
[[Category: Peptide deformylase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Choi K]]
[[Category: Choi, K.]]
[[Category: Kim EE]]
[[Category: Kim, E E.]]
[[Category: Kim K-H]]
[[Category: Kim, K H.]]
[[Category: Lee HK]]
[[Category: Lee, H K.]]
[[Category: Moon JH]]
[[Category: Moon, J H.]]
[[Category: Park HS]]
[[Category: Park, H S.]]
[[Category: hydrolase]]
[[Category: pdf]]
[[Category: peptide deformylase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:22:19 2008''
Retrieved from "https://proteopedia.org/2os1"