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==Crystal structure of the soluble domain of the mitochondrial calcium uniporter==
==Crystal structure of the soluble domain of the mitochondrial calcium uniporter==
<StructureSection load='6c5r' size='340' side='right' caption='[[6c5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6c5r' size='340' side='right'caption='[[6c5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c5r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Metaq Metaq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5R FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c5r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Metarhizium_acridum_CQMa_102 Metarhizium acridum CQMa 102]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C5R FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAC_01752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=655827 METAQ])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0960832&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5r OCA], [http://pdbe.org/6c5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5r RCSB], [http://www.ebi.ac.uk/pdbsum/6c5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5r OCA], [https://pdbe.org/6c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c5r RCSB], [https://www.ebi.ac.uk/pdbsum/6c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5r ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/E9DVV4_METAQ E9DVV4_METAQ]
Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called the mitochondrial calcium uniporter (MCU). Here, we determined the structures of the pore-forming MCU proteins from two fungi by X-ray crystallography and single-particle cryo-electron microscopy. The stoichiometry, overall architecture, and individual subunit structure differed markedly from those described in the recent nuclear magnetic resonance structure of Caenorhabditis elegans MCU. We observed a dimer-of-dimer architecture across species and chemical environments, which was corroborated by biochemical experiments. Structural analyses and functional characterization uncovered the roles of key residues in the pore. These results reveal a new ion channel architecture, provide insights into calcium coordination, selectivity and conduction, and establish a structural framework for understanding the mechanism of mitochondrial calcium uniporter function.


X-ray and cryo-EM structures of the mitochondrial calcium uniporter.,Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L Nature. 2018 Jul 11. pii: 10.1038/s41586-018-0330-9. doi:, 10.1038/s41586-018-0330-9. PMID:29995856<ref>PMID:29995856</ref>
==See Also==
 
*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6c5r" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Metaq]]
[[Category: Large Structures]]
[[Category: Fan, C]]
[[Category: Metarhizium acridum CQMa 102]]
[[Category: Fan, M]]
[[Category: Fan C]]
[[Category: Fastman, N]]
[[Category: Fan M]]
[[Category: Feng, L]]
[[Category: Fastman N]]
[[Category: Zhang, J]]
[[Category: Feng L]]
[[Category: Cytosolic protein]]
[[Category: Zhang J]]
Retrieved from "https://proteopedia.org/6c5r"