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==Crystal structure of the mitochondrial calcium uniporter==
==Crystal structure of the mitochondrial calcium uniporter==
<StructureSection load='6c5w' size='340' side='right' caption='[[6c5w]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6c5w' size='340' side='right'caption='[[6c5w]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c5w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Metaq Metaq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5W FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c5w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Metarhizium_acridum_CQMa_102 Metarhizium acridum CQMa 102] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C5W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1001024&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAC_01752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=655827 METAQ])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5w OCA], [http://pdbe.org/6c5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5w RCSB], [http://www.ebi.ac.uk/pdbsum/6c5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5w OCA], [https://pdbe.org/6c5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c5w RCSB], [https://www.ebi.ac.uk/pdbsum/6c5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCU_METAQ MCU_METAQ] Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix (PubMed:29995856). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (PubMed:29995856). Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit (PubMed:29995856).<ref>PMID:29995856</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c5w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c5w" style="background-color:#fffaf0;"></div>
==See Also==
*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Metaq]]
[[Category: Metarhizium acridum CQMa 102]]
[[Category: Fan, C]]
[[Category: Unidentified]]
[[Category: Fan, M]]
[[Category: Fan C]]
[[Category: Fastman, N]]
[[Category: Fan M]]
[[Category: Feng, L]]
[[Category: Fastman N]]
[[Category: Zhang, J]]
[[Category: Feng L]]
[[Category: Membrane protein]]
[[Category: Zhang J]]
Retrieved from "https://proteopedia.org/6c5w"