2m68: Difference between revisions
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==NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only)== | ==NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only)== | ||
<StructureSection load='2m68' size='340' side='right' caption='[[2m68 | <StructureSection load='2m68' size='340' side='right'caption='[[2m68]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m68]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2m68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M68 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m68 OCA], [https://pdbe.org/2m68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m68 RCSB], [https://www.ebi.ac.uk/pdbsum/2m68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m68 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MPRI_HUMAN MPRI_HUMAN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.<ref>PMID:10900005</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Crump | [[Category: Large Structures]] | ||
[[Category: Frago | [[Category: Crump MP]] | ||
[[Category: Garner | [[Category: Frago S]] | ||
[[Category: Hassan | [[Category: Garner L]] | ||
[[Category: Hoppe | [[Category: Hassan AB]] | ||
[[Category: Hughes | [[Category: Hoppe H]] | ||
[[Category: Minnall | [[Category: Hughes J]] | ||
[[Category: Prince | [[Category: Minnall L]] | ||
[[Category: Rezgui | [[Category: Prince SN]] | ||
[[Category: Richards | [[Category: Rezgui D]] | ||
[[Category: Strickland | [[Category: Richards E]] | ||
[[Category: Whittaker | [[Category: Strickland M]] | ||
[[Category: Williams | [[Category: Whittaker S]] | ||
[[Category: Zaccheo | [[Category: Williams C]] | ||
[[Category: Zaccheo OJ]] | |||
