6e5d: Difference between revisions

Latest revision as of 14:39, 13 March 2024

Crystal structure of LpqN involved in cell envelope biogenesis of Mycobacterium tuberculosis

Structural highlights

6e5d is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.65Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LPQN_MYCTU Involved in cell envelope biogenesis. May act as a membrane fusion protein, connecting MmpL transporters with periplasmic proteins, and play a role in cell envelope lipid changes during biofilm maturation.^[1] Is also a virulence factor required for intracellular survival (PubMed:30118682). Associates with CBL, a host ubiquitin ligase, and probably blocks the normal functions of CBL and disturbs CBL-mediated antibacterial activity (PubMed:30118682). Interaction counteracts antibacterial defense but causes a reciprocal enhancement of antiviral defense (PubMed:30118676, PubMed:30118682).^[2] ^[3]

References

↑ Melly GC, Stokas H, Dunaj JL, Hsu FF, Rajavel M, Su CC, Yu EW, Purdy GE. Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis. J Biol Chem. 2019 Oct 25;294(43):15711-15723. doi: 10.1074/jbc.RA119.008781. Epub, 2019 Aug 30. PMID:31471317 doi:https://dx.doi.org/10.1074/jbc.RA119.008781
↑ Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Mol Cell. 2018 Aug 16;71(4):637-648.e5. PMID:30118682 doi:10.1016/j.molcel.2018.07.010
↑ Eoh H, Jung JU. Bacterial Protein Reshapes Host Defense toward Antiviral Responses. Mol Cell. 2018 Aug 16;71(4):483-484. PMID:30118676 doi:10.1016/j.molcel.2018.08.006

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Melly GC, Stokas H, Dunaj JL, Hsu FF, Rajavel M, Su CC, Yu EW, Purdy GE. Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis. J Biol Chem. 2019 Oct 25;294(43):15711-15723. doi: 10.1074/jbc.RA119.008781. Epub, 2019 Aug 30. PMID:31471317 doi:https://dx.doi.org/10.1074/jbc.RA119.008781

[2] Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Ohol YM, Maher C, Bell SL, Geiger K, Golovkine G, Du X, Choi A, Parry T, Mohapatra BC, Storck MD, Band H, Chen C, Jäger S, Shales M, Portnoy DA, Hernandez R, Coscoy L, Cox JS, Krogan NJ. An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses. Mol Cell. 2018 Aug 16;71(4):637-648.e5. PMID:30118682 doi:10.1016/j.molcel.2018.07.010

[3] Eoh H, Jung JU. Bacterial Protein Reshapes Host Defense toward Antiviral Responses. Mol Cell. 2018 Aug 16;71(4):483-484. PMID:30118676 doi:10.1016/j.molcel.2018.08.006

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6e5d is ON HOLD  until Jul 20 2020
+==Crystal structure of LpqN involved in cell envelope biogenesis of Mycobacterium tuberculosis==
+<StructureSection load='6e5d' size='340' side='right'caption='[[6e5d]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e5d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5D FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5d OCA], [https://pdbe.org/6e5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5d RCSB], [https://www.ebi.ac.uk/pdbsum/6e5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LPQN_MYCTU LPQN_MYCTU] Involved in cell envelope biogenesis. May act as a membrane fusion protein, connecting MmpL transporters with periplasmic proteins, and play a role in cell envelope lipid changes during biofilm maturation.<ref>PMID:31471317</ref>   Is also a virulence factor required for intracellular survival (PubMed:30118682). Associates with CBL, a host ubiquitin ligase, and probably blocks the normal functions of CBL and disturbs CBL-mediated antibacterial activity (PubMed:30118682). Interaction counteracts antibacterial defense but causes a reciprocal enhancement of antiviral defense (PubMed:30118676, PubMed:30118682).<ref>PMID:30118682</ref> <ref>PMID:30118676</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Rajavel M]]
+[[Category: Su CC]]
+[[Category: Yu EW]]

6e5d: Difference between revisions

Latest revision as of 14:39, 13 March 2024

Crystal structure of LpqN involved in cell envelope biogenesis of Mycobacterium tuberculosis

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools