6eok: Difference between revisions
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New page: '''Unreleased structure''' The entry 6eok is ON HOLD Authors: Cerofolini, L., Giuntini, S., Carlon, A., Ravera, E., Calderone, V., Fragai, M., Parigi, G., Luchinat, C. Description: Cry... |
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==Crystal structure of E. coli L-asparaginase II== | |||
<StructureSection load='6eok' size='340' side='right'caption='[[6eok]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6eok]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EOK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eok OCA], [https://pdbe.org/6eok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eok RCSB], [https://www.ebi.ac.uk/pdbsum/6eok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eok ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ASPG2_ECOLI ASPG2_ECOLI] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Resonance assignment and structural characterization of pharmacologically-relevant proteins promises to improve their understanding and safety by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to "evade" the standard structural biology methodologies. We here demonstrate that it is possible to obtain the resonance assignment and a reliable structural model of large PEGylated proteins through an integrated approach encompassing NMR and X-ray crystallography. | |||
Characterization of PEGylated asparaginase: new opportunities from NMR analysis of large pegylated therapeutics.,Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C Chemistry. 2018 Nov 21. doi: 10.1002/chem.201804488. PMID:30462348<ref>PMID:30462348</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6eok" style="background-color:#fffaf0;"></div> | ||
[[Category: Calderone | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Asparaginase 3D structures|Asparaginase 3D structures]] | ||
[[Category: Fragai | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Ravera | </StructureSection> | ||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Calderone V]] | |||
[[Category: Carlon A]] | |||
[[Category: Cerofolini L]] | |||
[[Category: Fragai M]] | |||
[[Category: Giuntini S]] | |||
[[Category: Luchinat C]] | |||
[[Category: Parigi G]] | |||
[[Category: Ravera E]] | |||
Latest revision as of 12:36, 6 November 2024
Crystal structure of E. coli L-asparaginase II
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