2oyv: Difference between revisions

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[[Image:2oyv.jpg|left|200px]]


{{Structure
==Neurotensin in DPC micelles==
|PDB= 2oyv |SIZE=350|CAPTION= <scene name='initialview01'>2oyv</scene>
<StructureSection load='2oyv' size='340' side='right'caption='[[2oyv]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
<table><tr><td colspan='2'>[[2oyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OYV FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 14 models</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyv OCA], [https://pdbe.org/2oyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oyv RCSB], [https://www.ebi.ac.uk/pdbsum/2oyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oyv ProSAT]</span></td></tr>
|RELATEDENTRY=[[2oyw|2OYW]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyv OCA], [http://www.ebi.ac.uk/pdbsum/2oyv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oyv RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/NEUT_HUMAN NEUT_HUMAN] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
 
<div style="background-color:#fffaf0;">
'''Neurotensin in DPC micelles'''
== Publication Abstract from PubMed ==
 
 
==Overview==
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.


==About this Structure==
NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.,Coutant J, Curmi PA, Toma F, Monti JP Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729<ref>PMID:17441729</ref>
2OYV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA].
 
==Reference==
NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17441729 17441729]
[[Category: Protein complex]]
[[Category: Coutant, J.]]
[[Category: Curmi, P A.]]
[[Category: Monti, J P.]]
[[Category: type i turn]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:25:16 2008''
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2oyv" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Coutant J]]
[[Category: Curmi PA]]
[[Category: Monti JP]]

Latest revision as of 08:26, 30 October 2024

Neurotensin in DPC micelles

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