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==NMR Structure of KDM5B PHD1 finger==
==NMR Structure of KDM5B PHD1 finger==
<StructureSection load='2mny' size='340' side='right' caption='[[2mny]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mny' size='340' side='right'caption='[[2mny]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mny]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNY FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MNY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mnz|2mnz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDM5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [https://pdbe.org/2mny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [https://www.ebi.ac.uk/pdbsum/2mny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mny ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [http://pdbe.org/2mny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [http://www.ebi.ac.uk/pdbsum/2mny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mny ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Lysine-specific histone demethylase|Lysine-specific histone demethylase]]
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cao, C]]
[[Category: Large Structures]]
[[Category: Guo, X]]
[[Category: Cao C]]
[[Category: Lan, W X]]
[[Category: Guo X]]
[[Category: Rong, N Y]]
[[Category: Lan WX]]
[[Category: Song, Y J]]
[[Category: Rong NY]]
[[Category: Xu, Y H]]
[[Category: Song YJ]]
[[Category: Xu, Y W]]
[[Category: Xu YH]]
[[Category: Yang, H R]]
[[Category: Xu YW]]
[[Category: Zhang, Y]]
[[Category: Yang HR]]
[[Category: Demethylation]]
[[Category: Zhang Y]]
[[Category: H3k4]]
[[Category: Kdm5b]]
[[Category: Oxidoreductase]]
[[Category: Phd1]]
Retrieved from "https://proteopedia.org/2mny"