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==Solution Structure and Molecular determinants of Hemoglobin Binding of the first NEAT Domain of IsdB in Staphylococcus aureus==
==Solution Structure and Molecular determinants of Hemoglobin Binding of the first NEAT Domain of IsdB in Staphylococcus aureus==
<StructureSection load='2moq' size='340' side='right' caption='[[2moq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2moq' size='340' side='right'caption='[[2moq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2moq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staaw Staaw]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MOQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2moq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOQ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">isdB, frpB, sasJ, sirH, MW1011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=196620 STAAW])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2moq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moq OCA], [http://pdbe.org/2moq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2moq RCSB], [http://www.ebi.ac.uk/pdbsum/2moq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2moq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2moq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moq OCA], [https://pdbe.org/2moq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2moq RCSB], [https://www.ebi.ac.uk/pdbsum/2moq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2moq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISDB_STAAW ISDB_STAAW]] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence (By similarity). IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils.<ref>PMID:18097052</ref>
[https://www.uniprot.org/uniprot/ISDB_STAAW ISDB_STAAW] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence (By similarity). IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils.<ref>PMID:18097052</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Staaw]]
[[Category: Large Structures]]
[[Category: Copie, V]]
[[Category: Staphylococcus aureus subsp. aureus MW2]]
[[Category: Eilers, B J]]
[[Category: Copie V]]
[[Category: Fonner, B A]]
[[Category: Eilers BJ]]
[[Category: Lei, B]]
[[Category: Fonner BA]]
[[Category: Lui, M]]
[[Category: Lei B]]
[[Category: Moore, R]]
[[Category: Lui M]]
[[Category: Stanisich, J]]
[[Category: Moore R]]
[[Category: Sullivan-Springhetti, R K]]
[[Category: Stanisich J]]
[[Category: Tripet, B P]]
[[Category: Sullivan-Springhetti RK]]
[[Category: Hemoglobin receptor]]
[[Category: Tripet BP]]
[[Category: Iron surface determinant protein]]
[[Category: Isdb]]
[[Category: Metal binding protein]]
[[Category: Neat domain]]
[[Category: Protein binding]]
[[Category: Staphylococcus aureus]]
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