2nvj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase==
==NMR structures of transmembrane segment from subunit a from the yeast proton V-ATPase==
<StructureSection load='2nvj' size='340' side='right' caption='[[2nvj]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2nvj' size='340' side='right'caption='[[2nvj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2nvj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NVJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2nvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NVJ FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvj OCA], [http://pdbe.org/2nvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nvj RCSB], [http://www.ebi.ac.uk/pdbsum/2nvj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nvj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nvj OCA], [https://pdbe.org/2nvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nvj RCSB], [https://www.ebi.ac.uk/pdbsum/2nvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nvj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Duarte, A M]]
[[Category: Large Structures]]
[[Category: Hemminga, M A]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Jong, E R.de]]
[[Category: Duarte AM]]
[[Category: Mierlo, C P.van]]
[[Category: Hemminga MA]]
[[Category: Wechselberger, R]]
[[Category: Wechselberger R]]
[[Category: 10 helix]]
[[Category: De Jong ER]]
[[Category: Alfa helix]]
[[Category: Van Mierlo CP]]
[[Category: Hydrolase]]
[[Category: Pi helix]]
Retrieved from "https://proteopedia.org/2nvj"