5zz8: Difference between revisions

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'''Unreleased structure'''


The entry 5zz8 is ON HOLD
==Structure of the Herpes simplex virus type 2 C-capsid with capsid-vertex-specific component==
<SX load='5zz8' size='340' side='right' viewer='molstar' caption='[[5zz8]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5zz8]] is a 51 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_2 Human alphaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZZ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zz8 OCA], [https://pdbe.org/5zz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zz8 RCSB], [https://www.ebi.ac.uk/pdbsum/5zz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zz8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G9I260_HHV2 G9I260_HHV2] Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.[HAMAP-Rule:MF_04018]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the alpha-herpesvirinae subfamily that together with the beta- and gamma-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 A using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify alpha-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.


Authors: Wang, J.L., Yuan, S., Zhu, D.J., Tang, H., Wang, N., Chen, W.Y., Gao, Q., Li, Y.H., Wang, J.Z., Liu, H.R., Zhang, X.Z., Rao, Z.H., Wang, X.X.
Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component.,Wang J, Yuan S, Zhu D, Tang H, Wang N, Chen W, Gao Q, Li Y, Wang J, Liu H, Zhang X, Rao Z, Wang X Nat Commun. 2018 Sep 10;9(1):3668. doi: 10.1038/s41467-018-06078-4. PMID:30201968<ref>PMID:30201968</ref>


Description: Structure of the Herpes simplex virus type 2 C-capsid with capsid-vertex-specific component
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Wang, J.Z]]
<div class="pdbe-citations 5zz8" style="background-color:#fffaf0;"></div>
[[Category: Zhu, D.J]]
== References ==
[[Category: Liu, H.R]]
<references/>
[[Category: Zhang, X.Z]]
__TOC__
[[Category: Yuan, S]]
</SX>
[[Category: Rao, Z.H]]
[[Category: Human alphaherpesvirus 2]]
[[Category: Li, Y.H]]
[[Category: Large Structures]]
[[Category: Chen, W.Y]]
[[Category: Chen WY]]
[[Category: Gao, Q]]
[[Category: Gao Q]]
[[Category: Wang, J.L]]
[[Category: Li YH]]
[[Category: Wang, N]]
[[Category: Liu HR]]
[[Category: Tang, H]]
[[Category: Rao ZH]]
[[Category: Wang, X.X]]
[[Category: Tang H]]
[[Category: Wang JL]]
[[Category: Wang JZ]]
[[Category: Wang N]]
[[Category: Wang XX]]
[[Category: Yuan S]]
[[Category: Zhang XZ]]
[[Category: Zhu DJ]]
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