Pre-mRNA-splicing factor: Difference between revisions

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*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs.  For details see [[Prp24]]<br />
*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs.  For details see [[Prp24]]<br />
*For '''Prp19''' see [[Prp19]]<br />
*For '''Prp19''' see [[Prp19]]<br />
*For '''Prp20''' see [[Srp20-Human Alternative Splicing Factor]]<br />
*'''Prp31''' functions in forming the U4/U5-U6 tri-snRNP.<br />
*'''Prp31''' functions in forming the U4/U5-U6 tri-snRNP.<br />
*For '''Prp40''' see [[Prp40]].<br />
*For '''Prp40''' see [[Prp40]].<br />
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== Structural highlights ==
== Structural highlights ==
<scene name='46/462200/Cv/2'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>.
<scene name='46/462200/Cv/3'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>.
</StructureSection>


== 3D Structures of pre-mRNA splicing factors ==
== 3D Structures of pre-mRNA splicing factors ==
[[Pre-mRNA splicing factors 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Pre-mRNA-splicing factor 2
 
**[[3beg]] – hPrp P33 subunit + Ser/Thr-protein kinase – human<BR />
**[[2o3d]] – hPrp P33 subunit
 
*Pre-mRNA-splicing factor 3
 
**[[1x4q]] – hPrp PWI domain - NMR<BR />
**[[4yhu]], [[4yhv]] – yPrp C-terminal - yeast<br />
**[[4yhw]] – yPrp C-terminal + snRNA<br />
 
*Pre-mRNA-splicing factor 3B
 
**[[3lqv]], [[2f9d]], [[2f9j]] – hPrp residues 377-415 + pre-mRNA branch site protein 14<BR />
**[[2fho]] - hPrp residues 379-424 + spliceosomal protein P14 - NMR<BR />
**[[2do5]] – hPrp subunit 2 – NMR<BR />
**[[1x5t]] - hPrp subunit 4 – NMR<BR />
**[[5gvq]] - hPrp subunit 4 RNA-binding domain – NMR<BR />
**[[6en4]] - hPrp subunits 1,3,5 + SF3B14B<br />
**[[5ife]] - hPrp subunits 1,3,5 + PHD finger-like protein 5A <br />
**[[5zya]] - hPrp subunits 1,3,5 + PHD finger-like protein 5A + splicing modulator<br />
 
*Pre-mRNA-splicing factor 8
 
**[[3sbt]], [[4ilh]] – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 <br />
**[[4jk7]], [[4jk9]], [[3e9o]], [[3e9p]], [[3e66]] - yPrp RNA-binding domain <br />
**[[4ilj]], [[4jk8]], [[4jka]], [[4jkb]], [[4jkc]], [[4jkd]], [[4jke]], [[4jkf]], [[4jkg]], [[4jkh]]  - yPrp RNA-binding domain (mutant)<br />
**[[3zef]], [[4i43]] – yPrp + A1 cistron-splicing factor AAR2<br />
**[[2og4]], [[3sbg]] - yPrp Jab1/MPN domain<br />
**[[4bgd]], [[5dca]], [[5m52]], [[5m5p]] – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2<br />
**[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br />
**[[4ilg]] – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2 <br />
**[[3lru]] – hPrp residues 1831-1990<br />
**[[3e9l]], [[3enb]] – hPrp endonuclease domain<br />
**[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br />
**[[2p87]] – CePrp C terminal <br />
 
*Pre-mRNA-splicing factor 9
 
**[[4dgw]] – yPrp + Prp 21 + Prp 11
 
*Pre-mRNA-splicing factor 11
 
**[[4dgw]] – yPrp + Prp 21 + Prp 9
 
*Pre-mRNA-splicing factor 18
 
**[[2dk4]] – hPrp splicing factor motif domain - NMR<BR />
**[[1dvk]] – yPrp functional domain <br />
 
*Pre-mRNA-splicing factor 19
 
**[[3lrv]] – yPrp WD40 domain<BR />
**[[2bay]] – yPrp U-box<BR />
**[[1n87]] - yPrp U-box - NMR<BR />
 
*Pre-mRNA-splicing factor 20
 
**[[2i2y]] – Prp RNA-binding domain + RNA – ''Streptococcus'' – NMR<BR />
**[[2i38]] - hPrp RNA-binding domain (mutant) – NMR<BR />
 
*Pre-mRNA-splicing factor 21
 
**[[4dgw]] – yPrp + Prp 9 + Prp 11
 
*snRNA-associated-splicing factor 24
 
**[[2l9w]] – yPrp C terminal – NMR<BR />
**[[2kh9]] – yPrp residues 115-197 + RNA – NMR<BR />
**[[2go9]] – yPrp RNA-binding  domains – NMR<BR />
**[[2ghp]] - yPrp RNA-binding  domains
 
*Pre-mRNA-splicing factor 31
 
**[[2ozb]] – hPrp + RNA + tri-snRNP <br />
**[[3siu]], [[3siv]] – hPrp + NHP2-like protein + snRNP <br />
 
*Pre-mRNA-splicing factor 38A
 
**[[4rz9]], [[4rza]] – hPrp <br />
**[[5f5s]] – hPrp + microfibrillar-associated protein 1<br />
 
*Pre-mRNA-splicing factor 40
 
**[[1o6w]] – yPrp WW domain – yeast - NMR<br />
**[[2b7e]] – yPrp FF1 domain - NMR<br />
**[[2kfd]] – yPrp FF4 domain - NMR<br />
 
*Pre-mRNA-splicing factor 43P
 
**[[2xau]], [[3kx2]] – yPrp + ADP
 
*Pre-mRNA-splicing factors in spliceosome
 
**[[3jb9]] – yPrp <br />
**[[3jcm]], [[5gam]], [[5gan]], [[5gao]], [[5gap]], [[5gmk]], [[5lj3]], [[5lj5]], [[5lqw]], [[5mps]], [[5mq0]], [[5mqf]], [[5wsg]], [[6g90]], [[6exn]], [[6bk8]], [[5ylz]], [[5y88]] – yPrp - CryoEM<br />
**[[3jcr]], [[5o9z]] – hPrp - CryoEM<br />
 
*Pre-mRNA-splicing factor cwc2
 
**[[3tp2]], [[3u1l]], [[3u1m]] – yPrp <br />
 
*Pre-mRNA-splicing factor cwc26
 
**[[2mkc]] – yPrp + U2 SNRNP component IST3 + Pre-mRNA leakage protein<br />
**[[4uqt]] – yPrp + U2 SNRNP component IST3 <br />
 
*Pre-mRNA-splicing factor bud31
 
**[[2my1]] – yPrp - NMR<br />
 
 
*Pre-mRNA-splicing factor sad1
 
**[[4msx]] – yPrp <br />
 
 
*Pre-mRNA-splicing factor RBM22
 
**[[2ytc]] – yPrp RNA-binding domain - NMR<BR />
 
*Pre-mRNA-splicing factor RDS3
 
**[[2k0a]] – yPrp - NMR<BR />
 
*Pre-mRNA-splicing factor URN1
 
**[[2juc]] – yPrp FF domain - NMR<BR />
}}


== References ==
== References ==

Latest revision as of 09:17, 27 November 2019

Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (cyan) (PDB entry 3zef)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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