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[[Image:2pcg.jpg|left|200px]]


{{Structure
==Crystal structure of PH0725 from Pyrococcus horikoshii OT3==
|PDB= 2pcg |SIZE=350|CAPTION= <scene name='initialview01'>2pcg</scene>, resolution 2.20&Aring;
<StructureSection load='2pcg' size='340' side='right'caption='[[2pcg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
<table><tr><td colspan='2'>[[2pcg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PCG FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= dphB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pcg OCA], [https://pdbe.org/2pcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pcg RCSB], [https://www.ebi.ac.uk/pdbsum/2pcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pcg ProSAT], [https://www.topsan.org/Proteins/RSGI/2pcg TOPSAN]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pcg OCA], [http://www.ebi.ac.uk/pdbsum/2pcg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pcg RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pc/2pcg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pcg ConSurf].
<div style="clear:both"></div>


'''Crystal structure of PH0725 from Pyrococcus horikoshii OT3'''
==See Also==
 
*[[Diphthine synthase|Diphthine synthase]]
 
== References ==
==About this Structure==
<references/>
2PCG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PCG OCA].
__TOC__
[[Category: Diphthine synthase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
[[Category: Single protein]]
[[Category: Kageyama Y]]
[[Category: Kageyama, Y.]]
[[Category: Kunishima N]]
[[Category: Kunishima, N.]]
[[Category: Matsuura Y]]
[[Category: Matsuura, Y.]]
[[Category: Sugahara M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Taketa M]]
[[Category: Sugahara, M.]]
[[Category: Taketa, M.]]
[[Category: methyltransferase]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: pyrococcus horikoshii ot3]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: s-adenosyl-l-methionine]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:34:11 2008''

Latest revision as of 09:00, 25 October 2023

Crystal structure of PH0725 from Pyrococcus horikoshii OT3

2pcg, resolution 2.20Å

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