6hf7: Difference between revisions
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New page: '''Unreleased structure''' The entry 6hf7 is ON HOLD Authors: Engilberge, S., Wagner, T., Santoni, G., Breyton, C., Shima, S., Franzetti, B., Riobe, F., Maury, O., Girard, E. Descripti... |
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==Crystal structure of the adenylate kinase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4== | |||
<StructureSection load='6hf7' size='340' side='right'caption='[[6hf7]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hf7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HF7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MT:Tb-Xo4'>7MT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hf7 OCA], [http://pdbe.org/6hf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hf7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hf7 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Obtaining crystals and solving the phase problem remain major hurdles encountered by bio-crystallographers in their race to obtain new high-quality structures. Both issues can be overcome by the crystallophore, Tb-Xo4, a lanthanide-based molecular complex with unique nucleating and phasing properties. This article presents examples of new crystallization conditions induced by the presence of Tb-Xo4. These new crystalline forms bypass crystal defects often encountered by crystallographers, such as low-resolution diffracting samples or crystals with twinning. Thanks to Tb-Xo4's high phasing power, the structure determination process is greatly facilitated and can be extended to serial crystallography approaches. | |||
Protein crystal structure determination with the crystallophore, a nucleating and phasing agent.,Engilberge S, Wagner T, Santoni G, Breyton C, Shima S, Franzetti B, Riobe F, Maury O, Girard E J Appl Crystallogr. 2019 Jun 28;52(Pt 4):722-731. doi: 10.1107/S1600576719006381., eCollection 2019 Aug 1. PMID:31396026<ref>PMID:31396026</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6hf7" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Adenylate kinase]] | |||
[[Category: Large Structures]] | |||
[[Category: Methanothermococcus thermolithotrophicus]] | |||
[[Category: Breyton, C]] | |||
[[Category: Engilberge, S]] | |||
[[Category: Franzetti, B]] | |||
[[Category: Girard, E]] | |||
[[Category: Maury, O]] | [[Category: Maury, O]] | ||
[[Category: Riobe, F]] | [[Category: Riobe, F]] | ||
[[Category: Santoni, G]] | [[Category: Santoni, G]] | ||
[[Category: | [[Category: Shima, S]] | ||
[[Category: Wagner, T]] | |||
[[Category: Crystallophore]] | |||
[[Category: De novo phasing]] | |||
[[Category: Lanthanide complex]] | |||
[[Category: Molecular glue]] | |||
[[Category: Nucleation]] | |||
[[Category: Protein crystallization]] | |||
[[Category: Tb-xo4]] | |||
[[Category: Transferase]] | |||
Latest revision as of 06:31, 21 August 2019
Crystal structure of the adenylate kinase from Methanothermococcus thermolithotrophicus co-crystallized with Tb-Xo4
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