6m8h: Difference between revisions
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New page: '''Unreleased structure''' The entry 6m8h is ON HOLD Authors: Mascarenhas, R., Goossens, J., Leverson, B., Kothawala, S., Ballicora, M., Olsen, K., de freitas, D., Liu, D. Description:... |
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==Crystal Structure of the R208Q mutant of G(i) subunit alpha-1== | |||
<StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M8H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [https://pdbe.org/6m8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [https://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Ballicora M]] | |||
[[Category: Goossens J]] | |||
[[Category: Kothawala S]] | |||
[[Category: Leverson B]] | |||
[[Category: Liu D]] | |||
[[Category: Mascarenhas R]] | |||
[[Category: Olsen K]] | |||
[[Category: De freitas D]] | |||
Latest revision as of 14:41, 13 March 2024
Crystal Structure of the R208Q mutant of G(i) subunit alpha-1
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