2pku: Difference between revisions

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==Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2==
==Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2==
<StructureSection load='2pku' size='340' side='right' caption='[[2pku]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2pku' size='340' side='right'caption='[[2pku]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PKU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2pku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKU FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [http://pdbe.org/2pku PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [http://www.ebi.ac.uk/pdbsum/2pku PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pku OCA], [https://pdbe.org/2pku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pku RCSB], [https://www.ebi.ac.uk/pdbsum/2pku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pku ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>
[https://www.uniprot.org/uniprot/PICK1_RAT PICK1_RAT] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel.<ref>PMID:16138078</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Pan, L]]
[[Category: Rattus norvegicus]]
[[Category: Shen, C]]
[[Category: Pan L]]
[[Category: Shi, Y]]
[[Category: Shen C]]
[[Category: Wu, H]]
[[Category: Shi Y]]
[[Category: Xia, J]]
[[Category: Wu H]]
[[Category: Zhang, M]]
[[Category: Xia J]]
[[Category: Protein binding]]
[[Category: Zhang M]]
[[Category: Protein complex]]