Ubiquitin Structure & Function: Difference between revisions
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Infectious agents can manipulate ubiquitin or deubiquitination and one such protein is Chlamydia trachomatis. Chlamydia trachomatis' protein Cdu-1 catalyzes the hydrolysis of ubiquitin chains from Mcl-1. When polyubiquitnated, Mcl-1 is destined to be degraded by the proteasome, lowering the level of Mcl-1 and subsequently leading to apoptosis. The activity of Cdu-1 counteracts this by removing the ubiquitin, thus leading to higher levels of Mcl-1 in the cell. Additional information can be found here [[User:Karsten Theis/5B5Q]] | Infectious agents can manipulate ubiquitin or deubiquitination and one such protein is Chlamydia trachomatis. Chlamydia trachomatis' protein Cdu-1 catalyzes the hydrolysis of ubiquitin chains from Mcl-1. When polyubiquitnated, Mcl-1 is destined to be degraded by the proteasome, lowering the level of Mcl-1 and subsequently leading to apoptosis. The activity of Cdu-1 counteracts this by removing the ubiquitin, thus leading to higher levels of Mcl-1 in the cell. Additional information can be found here [[User:Karsten Theis/5B5Q]] | ||
SEE ALSO [[Tumor susceptibility gene 101]] | |||
</StructureSection> | </StructureSection> | ||
