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New page: '''Unreleased structure''' The entry 6hhq is ON HOLD Authors: Pellegrino, S., Vanderwal, C.D., Yusupov, M. Description: Crystal structure of compound C45 bound to the yeast 80S ribosom...
 
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'''Unreleased structure'''


The entry 6hhq is ON HOLD
==Crystal structure of compound C45 bound to the yeast 80S ribosome==
<StructureSection load='6hhq' size='340' side='right'caption='[[6hhq]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6hhq]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HHQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1000004&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G5B:(3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione'>G5B</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hhq OCA], [https://pdbe.org/6hhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hhq RCSB], [https://www.ebi.ac.uk/pdbsum/6hhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hhq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL2A_YEAST RL2A_YEAST]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Natural products that target the eukaryotic ribosome are promising therapeutics to treat a variety of cancers. It is therefore essential to determine their molecular mechanism of action to fully understand their mode of interaction with the target and to inform the development of new synthetic compounds with improved potency and reduced cytotoxicity. Toward this goal, we have previously established a short synthesis pathway that grants access to multiple congeners of the lissoclimide family. Here we present the X-ray co-crystal structure at 3.1 A resolution of C45, a potent congener with two A-ring chlorine-bearing stereogenic centers with 'unnatural' configurations, with the yeast 80S ribosome, intermolecular interaction energies of the C45/ribosome complex, and single-molecule FRET data quantifying the impact of C45 on both human and yeast ribosomes. Together, these data provide new insights into the role of unusual non-covalent halogen bonding interactions involved in the binding of this synthetic compound to the 80S ribosome.


Authors: Pellegrino, S., Vanderwal, C.D., Yusupov, M.
Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.,Pellegrino S, Meyer M, Konst ZA, Holm M, Voora VK, Kashinskaya D, Zanette C, Mobley DL, Yusupova G, Vanderwal CD, Blanchard SC, Yusupov M Nucleic Acids Res. 2019 Feb 13. pii: 5316741. doi: 10.1093/nar/gkz053. PMID:30759226<ref>PMID:30759226</ref>


Description: Crystal structure of compound C45 bound to the yeast 80S ribosome
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Pellegrino, S]]
<div class="pdbe-citations 6hhq" style="background-color:#fffaf0;"></div>
[[Category: Yusupov, M]]
 
[[Category: Vanderwal, C.D]]
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Pellegrino S]]
[[Category: Vanderwal CD]]
[[Category: Yusupov M]]
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