5yaw: Difference between revisions
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==Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction== | ==Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction== | ||
<StructureSection load='5yaw' size='340' side='right' caption='[[5yaw]], [[Resolution|resolution]] 2.03Å' scene=''> | <StructureSection load='5yaw' size='340' side='right'caption='[[5yaw]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5yaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAW OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5yaw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAW FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8SL:3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-methylpropyl)-4-(phenylmethyl)-1,2,4-triazole'>8SL</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.027Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8SL:3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-methylpropyl)-4-(phenylmethyl)-1,2,4-triazole'>8SL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaw OCA], [https://pdbe.org/5yaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yaw RCSB], [https://www.ebi.ac.uk/pdbsum/5yaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bing X]] | ||
[[Category: | [[Category: Danyan C]] | ||
[[Category: | [[Category: Yanlian L]] | ||
Latest revision as of 10:22, 27 March 2024
Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction
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