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==Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109==
==Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109==
<StructureSection load='6c57' size='340' side='right' caption='[[6c57]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6c57' size='340' side='right'caption='[[6c57]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c57]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C57 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C57 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FV9:{[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic+acid)'>FV9</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c57 OCA], [http://pdbe.org/6c57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c57 RCSB], [http://www.ebi.ac.uk/pdbsum/6c57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c57 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FV9:{[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic+acid)'>FV9</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c57 OCA], [https://pdbe.org/6c57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c57 RCSB], [https://www.ebi.ac.uk/pdbsum/6c57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c57 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GGPPS_HUMAN GGPPS_HUMAN]] Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.  
[https://www.uniprot.org/uniprot/GGPPS_HUMAN GGPPS_HUMAN] Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c57" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c57" style="background-color:#fffaf0;"></div>
==See Also==
*[[Geranylgeranyl pyrophosphate synthase 3D structures|Geranylgeranyl pyrophosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berghuis, A M]]
[[Category: Homo sapiens]]
[[Category: Bin, X]]
[[Category: Large Structures]]
[[Category: Park, J]]
[[Category: Berghuis AM]]
[[Category: Tsantrizos, Y S]]
[[Category: Bin X]]
[[Category: Vincent, F]]
[[Category: Park J]]
[[Category: Isopentenyl transferase]]
[[Category: Tsantrizos YS]]
[[Category: Isoprenoid pathway]]
[[Category: Vincent F]]
[[Category: Transferase]]
[[Category: Transferase inhibitor]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/6c57"