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| <StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'> | | <StructureSection load='' size='350' side='right' scene='51/510230/Cv/3' caption='SAM-dependent methyltransferase dimer complex with S-adenosyl-L-homocysteine and sulfate [[3ou6]]'> |
| == Function == | | == Function == |
| '''SAM-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids. SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation. About 120 members of the SDM family have been identified. They differ in their substrate specificity and the atom targeted for methylation (N, O, C, S)<ref>PMID:23180741</ref>. | | '''SAM-dependent methyltransferase''' or '''S-adenosylmethionine-dependent methyltransferase''' (SDM) utilizes the methyl donor S-adenosyl-L-methionine (SAM) as a cofactor to methylate proteins, small molecules, lipids and nucleic acids. SAM forms S-adenosyl-L-homocysteine (SAH) upon demethylation. About 120 members of the SDM family have been identified. They differ in their substrate specificity and the atom targeted for methylation ('''N, O, C, S''')<ref>PMID:23180741</ref>. |
| For '''Chemotaxis receptor methyltransferase CheR''' see details in [[Molecular Playground/CheR]].<ref>PMID:9628482</ref>.<br /> | | For '''Chemotaxis receptor methyltransferase CheR''' see details in [[Molecular Playground/CheR]].<ref>PMID:9628482</ref>.<br /> |
| *SEE ALSO [[Chemotaxis protein]]. | | *SEE ALSO [[Chemotaxis protein]]. |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='51/510230/Cv/2'>core of the SDM fold contains alternating β strands and α helices</scene>. SDM <scene name='51/510230/Cv/4'>active site is located between the 2 monomers</scene><ref>PMID:20876132</ref>. Water molecules shown as red spheres. | | The <scene name='51/510230/Cv/5'>core of the SDM fold contains alternating β strands and α helices</scene>. SDM <scene name='51/510230/Cv/6'>active site is located between the 2 monomers</scene><ref>PMID:20876132</ref>. Water molecules are shown as red spheres. |
| </StructureSection>
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| ==3D structures of SAM-dependent methyltrasferase== | | ==3D structures of SAM-dependent methyltrasferase== |
| | [[SAM-dependent methyltrasferase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *SAM-dependent O-methyltransferase
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| **[[1o54]] – TmSDM – ''Thermotoga maritima''<br />
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| **[[2hnk]] – SDM – ''Leptospira interrogans''<br />
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| **[[3r3h]] – SDM – ''Legionella pneumophila''<br />
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| **[[4qvk]] – PaSDM – ''Podospora anserina''<br />
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| **[[4ymg]] – PaSDM + SAM<br />
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| **[[4ymh]] – PaSDM + SAH<br />
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| **[[3ssm]], [[3sso]] – MgSDM + SAH – ''Micromonospora griseorubida''<br />
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| **[[3ssn]] – MgSDM + SAH + mycinamin <br />
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| *SAM-dependent N-methyltransferase
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| **[[1vlm]] – TmSDM (mutant)
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| *SAM-dependent C-methyltransferase
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| **[[4m72]] – ShSDM – ''Streptomyces hygroscopicus''<br />
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| **[[4m73]], [[4m74]] – ShSDM (mutant) <br />
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| **[[4kib]] – ShSDM + SAH + methylphenylpyruvate <br />
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| **[[4kic]] – ShSDM + SAM + phenylpyruvate <br />
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| **[[4kif]], [[4kig]] – ShSDM + phenylpyruvate <br />
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| **[[4m6x]], [[4m6y]], [[4m71]] – ShSDM (mutant) + SAH + methylphenylpyruvate <br />
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| **[[5o4h]] – MmHCGC + SAM + pyridinol - ''Methanococcus maripaludis'' <br />
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| **[[5o4n]], [[5o4j]], [[5o4m]] – MmHCGC + SAH + pyridinol <br />
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| *SAM-dependent methyltransferase
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| **[[1wzn]] – SDM – ''Pyrococcus horikoshii''<br />
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| **[[2igt]] – SDM –'' Agrobacterium tumefaciens''<br />
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| **[[3cgg]] – CgSDM – ''Corynebacterium glutamicum''<br />
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| **[[3d2l]] - SDM – ''Exiguobacterium sibiricum''<br />
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| **[[3dh0]] - SDM – ''Aquifex aeolicus''<br />
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| **[[3dp7]] - SDM – ''Bacterioides vulgatus''<br />
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| **[[3ggd]] - SDM – ''Anabaena variabilis''<br />
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| **[[3sm3]] - SDM (mutant) – ''Methanosarcina mazei''<br />
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| **[[3bkx]] – SDM – ''Lactobacillus casei''<br />
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| **[[3kr9]] – SpSDM – ''Streptococcus pneumonia''<br />
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| *SAM-dependent methyltransferase complex with SAM/SAH
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| **[[3ku1]] – SpSDM + SAM<br />
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| **[[3lga]] – PaSDM + SAH – ''Pyrococcus abyssi''<br />
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| **[[3mb5]] – PaSDM + SAM<br />
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| **[[3ou2]] – SlSDM + SAH – ''Streptomyces luridus''<br />
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| **[[3ou6]] – SlSDM + SAM<br />
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| **[[3ou7]] – SlSDM + SAM + phosphonic acid derivative<br />
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| **[[5gm1]] – SbSDM + SAH – ''Streptomyces blastmyceticus''<br />
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| **[[5gm2]] – SbSDM + SAH + teleocidin<br />
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| **[[4x3q]] – SDM + SAH – ''Streptosporangium sibiricum''<br />
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| **[[3h2b]] – CgSDM + pyrophosphate + SAH<br />
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| **[[5bp7]] – SlSDM + SAH – ''Geobacter sulfurreducens''<br />
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| **[[5epe]] – SDM + SAH –'' Thiobacillus denitrificans''<br />
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| **[[5bp9]] – SDM + SAH – ''Bacterioides fragilis''<br />
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| **[[2ybo]] – PsaSDM + SAH – ''Pseudomonas aeruginosa'' <br />
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| **[[2ybq]] – PsaSDM + SAH + uroporphyrinogen <br />
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| *Chemotaxis receptor methyltransferase (CheR)
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| **[[1af7]] – StCheR – ''Salmonella typhimurium''<br />
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| **[[1bc5]] – StCheR + chemotaxis receptor peptide
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
