6hn1: Difference between revisions
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New page: '''Unreleased structure''' The entry 6hn1 is ON HOLD Authors: Description: Category: Unreleased Structures |
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The | ==Complex of Caprine Serum Albumin with diclofenac== | ||
<StructureSection load='6hn1' size='340' side='right'caption='[[6hn1]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HN1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DIF:2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC+ACID'>DIF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn1 OCA], [https://pdbe.org/6hn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hn1 RCSB], [https://www.ebi.ac.uk/pdbsum/6hn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A452F7K4_CAPHI A0A452F7K4_CAPHI] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Free drug concentration in the blood sera is crucial for its appropriate activity. Serum albumin, the universal blood carrier protein, is responsible for transporting drugs and releasing them into the bloodstream. Therefore, a drug's binding to SA is especially important for its bioavailability and it is a key problem in the drug design process. In this paper, we present crystal structures of three animal serum albumin complexes: ovine, caprine, and leporine, with diclofenac, a popular non-steroidal anti-inflammatory drug that is used in therapy of chronic and acute pain. Details of diclofenac binding mode by the presented serum albumins are compared with analogous complexes of human and equine serum albumins. The analysis of the occupied binding pockets in crystal structures of the investigated serum albumins from different mammals shows that they have two common and a number of unique diclofenac binding sites. The most intriguing is the fact that the albumins from the described species are able to bind different numbers of molecules of this popular anti-inflammatory drug, but none of the binding sites overlap with ones in the human serum albumin. | |||
Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.,Talaj JA, Zielinski K, Bujacz A Int J Mol Sci. 2023 Jan 12;24(2):1534. doi: 10.3390/ijms24021534. PMID:36675044<ref>PMID:36675044</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6hn1" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Albumin 3D structures|Albumin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Capra hircus]] | |||
[[Category: Large Structures]] | |||
[[Category: Bujacz A]] | |||
[[Category: Bujacz G]] | |||
[[Category: Talaj JA]] | |||
Latest revision as of 05:18, 21 November 2024
Complex of Caprine Serum Albumin with diclofenac
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