6ie4: Difference between revisions
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==Crystal structure of ADCP1 tandem Agenet domain 1-2 in complex with H3K9me1== | |||
<StructureSection load='6ie4' size='340' side='right'caption='[[6ie4]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ie4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IE4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.696Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ie4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ie4 OCA], [https://pdbe.org/6ie4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ie4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ie4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ie4 ProSAT]</span></td></tr> | ||
[[Category: Li | </table> | ||
[[Category: Zhao | == Function == | ||
[https://www.uniprot.org/uniprot/AGDP1_ARATH AGDP1_ARATH] Heterochromatin-binding protein that preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, with a stronger affinity for dimethylated H3K9 (H3K9me2) (PubMed:30382101, PubMed:30425322). Required for transcriptional silencing, non-CG DNA methylation (e.g. CHG and CHH regions), and H3K9 dimethylation (H3K9me2) at some loci (PubMed:30382101, PubMed:30425322). Mediates heterochromatin phase separation and chromocenter formation (PubMed:30425322).<ref>PMID:30382101</ref> <ref>PMID:30425322</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Li H]] | |||
[[Category: Zhang B]] | |||
[[Category: Zhao S]] | |||
Latest revision as of 09:05, 9 April 2025
Crystal structure of ADCP1 tandem Agenet domain 1-2 in complex with H3K9me1
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