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[[Image:2q53.jpg|left|200px]]


{{Structure
==Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens==
|PDB= 2q53 |SIZE=350|CAPTION= <scene name='initialview01'>2q53</scene>, resolution 2.010&Aring;
<StructureSection load='2q53' size='340' side='right'caption='[[2q53]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
<table><tr><td colspan='2'>[[2q53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q53 FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
|GENE= C7orf24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06094 AIG2]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q53 OCA], [https://pdbe.org/2q53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q53 RCSB], [https://www.ebi.ac.uk/pdbsum/2q53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q53 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2i5t|2I5T]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q53 OCA], [http://www.ebi.ac.uk/pdbsum/2q53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q53 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/GGCT_HUMAN GGCT_HUMAN] Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.<ref>PMID:16765912</ref> <ref>PMID:18515354</ref>
 
== Evolutionary Conservation ==
'''Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q53_consurf.spt"</scriptWhenChecked>
2Q53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q53 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of Homo sapiens protein LOC79017., Bae E, Bingman CA, Aceti DJ, Phillips GN Jr, Proteins. 2008 Feb 1;70(2):588-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932939 17932939]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q53 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Kondrashov DA]]
[[Category: Jr., G N.Phillips.]]
[[Category: Levin EJ]]
[[Category: Kondrashov, D A.]]
[[Category: Phillips Jr GN]]
[[Category: Levin, E J.]]
[[Category: Wesenberg GE]]
[[Category: Wesenberg, G E.]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: ensemble refinement]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: refinement methodology development]]
[[Category: structural genomic]]
[[Category: unknown function]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:44:54 2008''

Latest revision as of 11:20, 30 August 2023

Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens

2q53, resolution 2.01Å

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