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==Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Glycochenodeoxycholic Acid==
==Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Glycochenodeoxycholic Acid==
<StructureSection load='6e47' size='340' side='right' caption='[[6e47]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6e47' size='340' side='right'caption='[[6e47]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6e47]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E47 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6e47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E47 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lq6|3lq6]], [[6e48|6e48]], [[6c6q|6c6q]], [[6c74|6c74]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHO:GLYCOCHENODEOXYCHOLIC+ACID'>CHO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD300lf, CLM1, DIR2, IREM1, LMIR3, PIGR3, IgSF13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e47 OCA], [https://pdbe.org/6e47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e47 RCSB], [https://www.ebi.ac.uk/pdbsum/6e47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e47 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e47 OCA], [http://pdbe.org/6e47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e47 RCSB], [http://www.ebi.ac.uk/pdbsum/6e47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e47 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLM1_MOUSE CLM1_MOUSE]] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.<ref>PMID:14662855</ref> <ref>PMID:17438331</ref> <ref>PMID:18097021</ref>
[https://www.uniprot.org/uniprot/CAPSD_MNV1 CAPSD_MNV1] Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and is decorated with VP2 proteins (By similarity). Mediates virion attachment to the host cell receptor CD300LF (PubMed:27540007, PubMed:30194229).[UniProtKB:Q83884]<ref>PMID:27540007</ref> <ref>PMID:30194229</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6e47" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6e47" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Murine norovirus 1]]
[[Category: Murine norovirus 1]]
[[Category: Fremont, D H]]
[[Category: Mus musculus]]
[[Category: Nelson, C A]]
[[Category: Fremont DH]]
[[Category: Bile acid]]
[[Category: Nelson CA]]
[[Category: Capsid protein]]
[[Category: Clm-1]]
[[Category: Clm1]]
[[Category: Cmrf-35-like molecule-1]]
[[Category: Dir2]]
[[Category: Gcdca]]
[[Category: Igsf13]]
[[Category: Irem1]]
[[Category: Lmir3]]
[[Category: Myeloid receptor]]
[[Category: Norovirus]]
[[Category: Pigr3]]
[[Category: Protruding domain]]
[[Category: Viral protein]]
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