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==Crystal Structure of the Botulinum Neurotoxin serotype G binding domain==
==Crystal Structure of the Botulinum Neurotoxin serotype G binding domain==
<StructureSection load='2vxr' size='340' side='right' caption='[[2vxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2vxr' size='340' side='right'caption='[[2vxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vxr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zb7|1zb7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxr OCA], [http://pdbe.org/2vxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxr RCSB], [http://www.ebi.ac.uk/pdbsum/2vxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxr OCA], [https://pdbe.org/2vxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxr RCSB], [https://www.ebi.ac.uk/pdbsum/2vxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BXG_CLOBO BXG_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Botulinum neurotoxin|Botulinum neurotoxin]]
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Clostridium botulinum]]
[[Category: Dupuy, J]]
[[Category: Large Structures]]
[[Category: Stenmark, P]]
[[Category: Dupuy J]]
[[Category: Stevens, R C]]
[[Category: Stenmark P]]
[[Category: Binding domain]]
[[Category: Stevens RC]]
[[Category: Botulinum]]
[[Category: Ganglioside]]
[[Category: Hydrolase]]
[[Category: Metalloprotease]]
[[Category: Neurotoxin]]
[[Category: Protease]]
[[Category: Receptor]]
[[Category: Secreted]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2vxr"