2vqz: Difference between revisions
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==Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP== | ==Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP== | ||
<StructureSection load='2vqz' size='340' side='right' caption='[[2vqz]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2vqz' size='340' side='right'caption='[[2vqz]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vqz]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vqz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQZ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqz OCA], [https://pdbe.org/2vqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqz RCSB], [https://www.ebi.ac.uk/pdbsum/2vqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqz ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PB2_I75A3 PB2_I75A3] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Coloma | [[Category: Influenza A virus]] | ||
[[Category: Crepin | [[Category: Large Structures]] | ||
[[Category: Cusack | [[Category: Coloma R]] | ||
[[Category: Guilligay | [[Category: Crepin T]] | ||
[[Category: Hart | [[Category: Cusack S]] | ||
[[Category: Lewis | [[Category: Guilligay D]] | ||
[[Category: Ortin | [[Category: Hart DJ]] | ||
[[Category: Resa-Infante | [[Category: Lewis J]] | ||
[[Category: Ruigrok | [[Category: Ortin J]] | ||
[[Category: Sehr | [[Category: Resa-Infante P]] | ||
[[Category: Tarendeau | [[Category: Ruigrok RWH]] | ||
[[Category: Sehr P]] | |||
[[Category: Tarendeau F]] | |||
