Tissue factor pathway inhibitor: Difference between revisions
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The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>. | The expression of hTFPI-2 in tumors is inversely related to their malignancy<ref>PMID:18000791</ref>. TFPI inhibitors are investigated as therapeutic agents agains hemophilia<ref>PMID:27207418</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/ | In the complex of TFPI-2 and trypsin, <scene name='70/707370/Cv/6'>hydrophobic residues of TFPI-2 interact with hydrophobic patch</scene> of trypsin. An <scene name='70/707370/Cv/7'>Arg residue which is the P1 residue of TFPI-2 interacts with Asp - the S1 residue</scene> of trypsin<ref>PMID:15932872</ref>. <scene name='70/707370/Cv/8'>Ca coordination site</scene>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
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[[1irh]] – hTFPI-1 kunitz domain III - NMR<br /> | [[1irh]] – hTFPI-1 kunitz domain III - NMR<br /> | ||
[[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br /> | [[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br /> | ||
[[6bx8]] – hTFPI-1 kunitz domain I (mutant) + trypsin <br /> | |||
[[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br /> | [[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br /> | ||
[[5nmv]] – hTFPI-1 kunitz domain I + antibody <br /> | [[5nmv]] – hTFPI-1 kunitz domain I + antibody <br /> | ||
[[4dtg]] – hTFPI-1 kunitz domain II + antibody <br /> | [[4dtg]] – hTFPI-1 kunitz domain II + antibody <br /> | ||
[[4bqd]] – hTFPI-1 kunitz domain I + peptide <br /> | [[4bqd]] – hTFPI-1 kunitz domain I + peptide <br /> | ||
[[7v1n]] – hTFPI-1 + toxin B <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:20, 25 April 2022
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3D Structures of tissue factor pathway inhibitor
Updated on 25-April-2022
Tissue factor pathway inhibitor domains: kunitz I 29-118; kunitz II 121-178; kunitz III 210-270
1adz – hTFPI-1 kunitz domain II (mutant) – human - NMR
1irh – hTFPI-1 kunitz domain III - NMR
1tfx – hTFPI-1 kunitz domain II + trypsin
6bx8 – hTFPI-1 kunitz domain I (mutant) + trypsin
1zr0 – hTFPI-2 kunitz domain I + trypsin
5nmv – hTFPI-1 kunitz domain I + antibody
4dtg – hTFPI-1 kunitz domain II + antibody
4bqd – hTFPI-1 kunitz domain I + peptide
7v1n – hTFPI-1 + toxin B
