6mib: Difference between revisions
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New page: '''Unreleased structure''' The entry 6mib is ON HOLD Authors: Fukuda, K., Qin, J. Description: Crystal structure of the ILK mutant (L207W)/alpha-parvin core complex [[Category: Unrelea... |
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==Crystal structure of the ILK ATP-binding deficient mutant (L207W)/alpha-parvin core complex== | |||
<StructureSection load='6mib' size='340' side='right'caption='[[6mib]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MIB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mib OCA], [https://pdbe.org/6mib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mib RCSB], [https://www.ebi.ac.uk/pdbsum/6mib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mib ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | |||
==See Also== | |||
*[[Parvin 3D structures|Parvin 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Fukuda | [[Category: Homo sapiens]] | ||
[[Category: Qin | [[Category: Large Structures]] | ||
[[Category: Fukuda K]] | |||
[[Category: Qin J]] | |||
