6ed3: Difference between revisions

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==Mtb ClpB in complex with AMPPNP==
==Mtb ClpB in complex with AMPPNP==
<StructureSection load='6ed3' size='340' side='right' caption='[[6ed3]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
<SX load='6ed3' size='340' side='right' viewer='molstar' caption='[[6ed3]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ed3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ED3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ed3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ED3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ED3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed3 OCA], [http://pdbe.org/6ed3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ed3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ed3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed3 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ed3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ed3 OCA], [https://pdbe.org/6ed3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ed3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ed3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ed3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLPB_MYCTO CLPB_MYCTO]] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).  
[https://www.uniprot.org/uniprot/CLPB_MYCTU CLPB_MYCTU] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
 
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
*[[3D structures of ClpB|3D structures of ClpB]]
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Li, H L]]
[[Category: Large Structures]]
[[Category: Yu, H J]]
[[Category: Aaa atpase]]
[[Category: Chaperone]]
[[Category: Cryoem]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pathogen]]
[[Category: Li HL]]
[[Category: Unfoldase]]
[[Category: Yu HJ]]
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