2qf4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2qf4.jpg|left|200px]]


{{Structure
==High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)==
|PDB= 2qf4 |SIZE=350|CAPTION= <scene name='initialview01'>2qf4</scene>, resolution 1.200&Aring;
<StructureSection load='2qf4' size='340' side='right'caption='[[2qf4]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2qf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QF4 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
|GENE= mreC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 Streptococcus pneumoniae R6])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qf4 OCA], [https://pdbe.org/2qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qf4 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2qf5|2QF5]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qf4 OCA], [http://www.ebi.ac.uk/pdbsum/2qf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qf4 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/MREC_STRR6 MREC_STRR6] Involved in formation and maintenance of cell shape.[UniProtKB:Q01466]
 
== Evolutionary Conservation ==
'''High resolution structure of the major periplasmic domain from the cell shape-determining filament MreC (orthorhombic form)'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/2qf4_consurf.spt"</scriptWhenChecked>
Bacterial cell shape is dictated by the cell wall, a plastic structure that must adapt to growth and division whilst retaining its function as a selectively permeable barrier. The modulation of cell wall structure is achieved by a variety of enzymatic functions, all of which must be spatially regulated in a precise manner. The membrane-spanning essential protein MreC has been identified as the central hub in this process, linking the bacterial cytoskeleton to a variety of cell wall-modifying enzymes. Additionally, MreC can form filaments, believed to run perpendicularly to the membrane. We present here the 1.2 A resolution crystal structure of the major periplasmic domain of Streptococcus pneumoniae MreC. The protein shows a novel arrangement of two barrel-shaped domains, one of which shows homology to a known protein oligomerization motif, with the other resembling a catalytic domain from a bacterial protease. We discuss the implications of these results for MreC function, and detail the structural features of the molecule that may be responsible for the binding of partner proteins.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2QF4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QF4 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qf4 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC., Lovering AL, Strynadka NC, J Mol Biol. 2007 Sep 28;372(4):1034-44. Epub 2007 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17707860 17707860]
</StructureSection>
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae r6]]
[[Category: Streptococcus pneumoniae R6]]
[[Category: Lovering, A L.]]
[[Category: Lovering AL]]
[[Category: Strynadka, N C.J.]]
[[Category: Strynadka NCJ]]
[[Category: filament a-lytic protease fold]]
[[Category: structural protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:33 2008''
Retrieved from "https://proteopedia.org/2qf4"