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==Yeast V-ATPase transmembrane helix 7 NMR structure in DPC micelles==
==Yeast V-ATPase transmembrane helix 7 NMR structure in DPC micelles==
<StructureSection load='6hh0' size='340' side='right' caption='[[6hh0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='6hh0' size='340' side='right'caption='[[6hh0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HH0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HH0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VPH1, YOR270C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hh0 OCA], [http://pdbe.org/6hh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hh0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hh0 OCA], [https://pdbe.org/6hh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hh0 RCSB], [https://www.ebi.ac.uk/pdbsum/6hh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hh0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:11278748, PubMed:1491220, PubMed:8798414). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:11278748, PubMed:1491220). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:11278748, PubMed:8798414).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hh0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hh0" style="background-color:#fffaf0;"></div>
==See Also==
*[[ATPase 3D structures|ATPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Hohlweg, W]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Wagner, G]]
[[Category: Hohlweg W]]
[[Category: Zangger, K]]
[[Category: Wagner G]]
[[Category: Atpasse]]
[[Category: Zangger K]]
[[Category: Dpc micelle]]
[[Category: Membrane protein]]
[[Category: Nmr spectroscopy]]
[[Category: Transmembrane helix]]
Retrieved from "https://proteopedia.org/6hh0"