2w9l: Difference between revisions

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==CANINE ADENOVIRUS TYPE 2 FIBRE HEAD IN COMPLEX WITH CAR DOMAIN D1 AND SIALIC ACID==
==CANINE ADENOVIRUS TYPE 2 FIBRE HEAD IN COMPLEX WITH CAR DOMAIN D1 AND SIALIC ACID==
<StructureSection load='2w9l' size='340' side='right' caption='[[2w9l]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
<StructureSection load='2w9l' size='340' side='right'caption='[[2w9l]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2w9l]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Adec2 Adec2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W9L FirstGlance]. <br>
<table><tr><td colspan='2'>[[2w9l]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_adenovirus_2 Canine adenovirus 2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W9L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GL0:BETA-D-GULOPYRANOSE'>GL0</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j12|2j12]], [[1eaj|1eaj]], [[1p69|1p69]], [[1jew|1jew]], [[1kac|1kac]], [[2j2j|2j2j]], [[1p6a|1p6a]], [[1rsf|1rsf]], [[1f5w|1f5w]], [[2j1k|2j1k]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GL0:BETA-D-GULOPYRANOSE'>GL0</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w9l OCA], [http://pdbe.org/2w9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w9l RCSB], [http://www.ebi.ac.uk/pdbsum/2w9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w9l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w9l OCA], [https://pdbe.org/2w9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w9l RCSB], [https://www.ebi.ac.uk/pdbsum/2w9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w9l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/2w9l_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/2w9l_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adec2]]
[[Category: Canine adenovirus 2]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Billet, O]]
[[Category: Large Structures]]
[[Category: Cusack, S]]
[[Category: Billet O]]
[[Category: Dreja, H]]
[[Category: Cusack S]]
[[Category: Finberg, R W]]
[[Category: Dreja H]]
[[Category: Henaff, D]]
[[Category: Finberg RW]]
[[Category: Hippert, C]]
[[Category: Henaff D]]
[[Category: Ibanes, S]]
[[Category: Hippert C]]
[[Category: Kalatzis, V]]
[[Category: Ibanes S]]
[[Category: Kremer, E J]]
[[Category: Kalatzis V]]
[[Category: Lortat-Jacob, H]]
[[Category: Kremer EJ]]
[[Category: Mennechet, F]]
[[Category: Lortat-Jacob H]]
[[Category: Perreau, M]]
[[Category: Mennechet F]]
[[Category: Schoehn, G]]
[[Category: Perreau M]]
[[Category: Seiradake, E]]
[[Category: Schoehn G]]
[[Category: Wang, J P]]
[[Category: Seiradake E]]
[[Category: Wodrich, H]]
[[Category: Wang JP]]
[[Category: Adenovirus]]
[[Category: Wodrich H]]
[[Category: Canine]]
[[Category: Car]]
[[Category: Cav-2]]
[[Category: Cell adhesion]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Complex]]
[[Category: Coxsackievirus]]
[[Category: Domain d1]]
[[Category: Erythrocyte]]
[[Category: Fiber]]
[[Category: Fiber head]]
[[Category: Fiber protein]]
[[Category: Fibre]]
[[Category: Fibre head]]
[[Category: Glycoprotein]]
[[Category: Hemagglutination]]
[[Category: Host-virus interaction]]
[[Category: Immunoglobulin domain]]
[[Category: Knob]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Palmitate]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Receptor]]
[[Category: Red blood cell]]
[[Category: Secreted]]
[[Category: Sialic acid]]
[[Category: Sialyl-lactose]]
[[Category: Tight junction]]
[[Category: Transmembrane]]
[[Category: Virus-receptor complex]]
Retrieved from "https://proteopedia.org/2w9l"