2wdt: Difference between revisions

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==Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME==
==Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME==
<StructureSection load='2wdt' size='340' side='right' caption='[[2wdt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2wdt' size='340' side='right'caption='[[2wdt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WDT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wdt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WDT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GVE:METHYL+4-AMINOBUTANOATE'>GVE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xqq|1xqq]], [[2jf5|2jf5]], [[2gbj|2gbj]], [[1ubq|1ubq]], [[1zgu|1zgu]], [[2g45|2g45]], [[2gbk|2gbk]], [[2j7q|2j7q]], [[1f9j|1f9j]], [[2bgf|2bgf]], [[1fxt|1fxt]], [[1tbe|1tbe]], [[2ayo|2ayo]], [[1xd3|1xd3]], [[1gjz|1gjz]], [[1ubi|1ubi]], [[1g6j|1g6j]], [[1nbf|1nbf]], [[1sif|1sif]], [[1d3z|1d3z]], [[2w9n|2w9n]], [[1ogw|1ogw]], [[2gbn|2gbn]], [[2gbm|2gbm]], [[1yx5|1yx5]], [[1c3t|1c3t]], [[1q5w|1q5w]], [[1s1q|1s1q]], [[1yx6|1yx6]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdt OCA], [https://pdbe.org/2wdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wdt RCSB], [https://www.ebi.ac.uk/pdbsum/2wdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdt ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wdt OCA], [http://pdbe.org/2wdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wdt RCSB], [http://www.ebi.ac.uk/pdbsum/2wdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wdt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UCHL3_PLAF7 UCHL3_PLAF7] Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8 (PubMed:17371404, PubMed:20042598, PubMed:31658303). Essential for parasite blood stage survival (PubMed:20042598).<ref>PMID:17371404</ref> <ref>PMID:20042598</ref> <ref>PMID:31658303</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdt_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wd/2wdt_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Thioesterase|Thioesterase]]
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
*[[Ubiquitin|Ubiquitin]]
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Plafa]]
[[Category: Large Structures]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Plasmodium falciparum]]
[[Category: Artavanis-Tsakonas, K]]
[[Category: Artavanis-Tsakonas K]]
[[Category: Gaudet, R]]
[[Category: Gaudet R]]
[[Category: Ploegh, H L]]
[[Category: Ploegh HL]]
[[Category: Weihofen, W A]]
[[Category: Weihofen WA]]
[[Category: Cystein proteinase]]
[[Category: Enzyme-ligand complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase-protein binding complex]]
[[Category: Peptidase_c12]]
[[Category: Ubiquitin isopeptidase]]
[[Category: Uch-l superfamily]]
Retrieved from "https://proteopedia.org/2wdt"