2wc2: Difference between revisions
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==Nmr structure of catabolite activator protein in the unliganded state== | ==Nmr structure of catabolite activator protein in the unliganded state== | ||
<StructureSection load='2wc2' size='340' side='right' caption='[[2wc2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2wc2' size='340' side='right'caption='[[2wc2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wc2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wc2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WC2 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wc2 OCA], [https://pdbe.org/2wc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wc2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wc2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/CRP_ECO57 CRP_ECO57]] A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Catabolite gene activator protein|Catabolite gene activator protein]] | *[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Ecobd]] | [[Category: Ecobd]] | ||
[[Category: Large Structures]] | |||
[[Category: Kalodimos, C G]] | [[Category: Kalodimos, C G]] | ||
[[Category: Popovych, N]] | [[Category: Popovych, N]] | ||
