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==Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)==
==Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known Vector (NKV)==
<StructureSection load='2wa2' size='340' side='right' caption='[[2wa2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2wa2' size='340' side='right'caption='[[2wa2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Modv Modv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WA2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Modoc_virus Modoc virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WA2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wa1|2wa1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa2 OCA], [http://pdbe.org/2wa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wa2 RCSB], [http://www.ebi.ac.uk/pdbsum/2wa2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wa2 OCA], [https://pdbe.org/2wa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wa2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wa2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8QL64_9FLAV Q8QL64_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317]  Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504]  Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Modv]]
[[Category: Large Structures]]
[[Category: Jansson, A M]]
[[Category: Johansson, P]]
[[Category: Jones, T A]]
[[Category: 2'-o-methyltransferase]]
[[Category: Envelope protein]]
[[Category: Flavivirus]]
[[Category: Membrane]]
[[Category: Methyltransferase]]
[[Category: Modoc virus]]
[[Category: Modoc virus]]
[[Category: N7-methyltransferase]]
[[Category: Jansson AM]]
[[Category: S-adenosyl-l- methionine]]
[[Category: Johansson P]]
[[Category: Transferase]]
[[Category: Jones TA]]
[[Category: Transmembrane]]
[[Category: Virion]]
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