TNF receptor-associated factor: Difference between revisions

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__TOC__

== Function ==

'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.

'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.

*'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.

*'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.

*'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.

*'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.

== Structural highlights ==

The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/3'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}

The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}

~~</StructureSection>~~

== 3D Structures of TNF receptor-associated factor ==

[[TNF receptor-associated factor 3D structures]]

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

</StructureSection>

~~{{#tree:id=OrganizedByTopic|openlevels=0|~~

*TRAF1

**[[5e1t]] – hTRAF1 TRAF domain - human

**[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2

**[[5h10]] – hTRAF1 TRAF domain + TANK peptide

*TRAF2

**[[1ca4]] – hTRAF2 TRAF domain

**[[3knv]] – hTRAF2 RING+zinc finger 1 domains

**[[3m06]] – hTRAF2 residues 266-329

*TRAF2 complex with peptide

**[[1ca9]] – hTRAF2 TRAF domain + TNF-R2 peptide

**[[1qsc]], [[1d00]], [[1czz]] – hTRAF2 TRAF domain + CD40 receptor peptide

**[[1d01]] – hTRAF2 TRAF domain + CD30 peptide

**[[1czy]] – hTRAF2 TRAF domain + latent membrane protein peptide

**[[1d0a]] – hTRAF2 TRAF domain + OX40L receptor peptide

**[[1d0j]] – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide

**[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal

**[[3m0a]] – hTRAF2 residues 266-329 + cIAP2

*TRAF3

**[[4ghu]] – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse

*TRAF4

**[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain

**[[5yc1]] – hTRAF4 TRAF domain + GLIB peptide

*TRAF5

**[[4gjh]] – hTRAF5 TRAF domain

*TRAF6; domains: RING 50-124; zinc finger 1 125-159;zinc fingers 2,3 160-211; TRAF 346-504

**[[1lb4]] – hTRAF6 TRAF domain

**[[2jmd]], [[2eci]] – hTRAF6 RING domain - NMR

**[[3hcs]] – hTRAF6 RING+zinc finger 1-3 domains

*TRAF6 complex with peptide

**[[1lb5]] – hTRAF6 TRAF domain + RANK peptide

**[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide

**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2

**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide

**[[5vnz]], [[5vo0]] – TRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish

}}

== References ==

[[Category:Topic Page]]

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 <StructureSection load='' size='350' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'>
+__TOC__
 == Function ==
-'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.  '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.  '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.  '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.  '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
+'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.
+*'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.
+*'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
+*'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.
+*'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
 == Structural highlights ==
-The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/3'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}
+The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}
-</StructureSection>
 == 3D Structures of TNF receptor-associated factor ==
+[[TNF receptor-associated factor 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*TRAF1
-**[[5e1t]] – hTRAF1 TRAF domain - human<br />
-**[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 <br />
-**[[5h10]] – hTRAF1 TRAF domain + TANK peptide <br />
-*TRAF2
-**[[1ca4]] – hTRAF2 TRAF domain<br />
-**[[3knv]] – hTRAF2 RING+zinc finger 1 domains <br />
-**[[3m06]] – hTRAF2 residues 266-329 <br />
-*TRAF2 complex with peptide
-**[[1ca9]] – hTRAF2 TRAF domain + TNF-R2 peptide<br />
-**[[1qsc]], [[1d00]], [[1czz]] – hTRAF2 TRAF domain + CD40 receptor peptide<br />
-**[[1d01]] – hTRAF2 TRAF domain + CD30 peptide<br />
-**[[1czy]] – hTRAF2 TRAF domain + latent membrane protein peptide<br />
-**[[1d0a]] – hTRAF2 TRAF domain + OX40L receptor peptide<br />
-**[[1d0j]] – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide<br />
-**[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br />
-**[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br />
-*TRAF3
-**[[4ghu]] – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse <br />
-*TRAF4
-**[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain <br />
-**[[5yc1]] – hTRAF4 TRAF domain + GLIB peptide <br />
-*TRAF5
-**[[4gjh]] – hTRAF5 TRAF domain <br />
-*TRAF6; domains: RING 50-124; zinc finger 1 125-159;zinc fingers 2,3 160-211; TRAF 346-504
-**[[1lb4]] – hTRAF6 TRAF domain <br />
-**[[2jmd]], [[2eci]] – hTRAF6 RING domain - NMR<br />
-**[[3hcs]] – hTRAF6 RING+zinc finger 1-3 domains <br />
-*TRAF6 complex with peptide
-**[[1lb5]] – hTRAF6 TRAF domain + RANK peptide<br />
-**[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br />
-**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br />
-**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br />
-**[[5vnz]], [[5vo0]] – TRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]