6mju: Difference between revisions
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New page: '''Unreleased structure''' The entry 6mju is ON HOLD Authors: Description: Category: Unreleased Structures |
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==human cGAS catalytic domain bound with the inhibitor G108== | |||
<StructureSection load='6mju' size='340' side='right'caption='[[6mju]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUM:1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mju OCA], [https://pdbe.org/6mju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mju RCSB], [https://www.ebi.ac.uk/pdbsum/6mju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mju ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | |||
==See Also== | |||
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Adura C]] | |||
[[Category: Aida J]] | |||
[[Category: Asano Y]] | |||
[[Category: Gao P]] | |||
[[Category: Glickman JF]] | |||
[[Category: Gogakos T]] | |||
[[Category: Hashizume S]] | |||
[[Category: Imaeda T]] | |||
[[Category: Jennings AJ]] | |||
[[Category: Kamei T]] | |||
[[Category: Kuroita T]] | |||
[[Category: Kuryavyi V]] | |||
[[Category: Lama L]] | |||
[[Category: Meinke P]] | |||
[[Category: Michinom M]] | |||
[[Category: Miller M]] | |||
[[Category: Okamoto R]] | |||
[[Category: Patel DJ]] | |||
[[Category: Ramos-Espiritu L]] | |||
[[Category: Stamford A]] | |||
[[Category: Steinberg JI]] | |||
[[Category: Tomita D]] | |||
[[Category: Tuschl T]] | |||
[[Category: Xie W]] | |||
Latest revision as of 14:43, 13 March 2024
human cGAS catalytic domain bound with the inhibitor G108
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