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| ==Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)== | | ==Alternative composite structure of the inner ring of the human nuclear pore complex (16 copies of Nup188, 16 copies of Nup205)== |
| <StructureSection load='5ijo' size='340' side='right' caption='[[5ijo]], [[Resolution|resolution]] 21.40Å' scene=''> | | <SX load='5ijo' size='340' side='right' viewer='molstar' caption='[[5ijo]], [[Resolution|resolution]] 21.40Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[5ijo]] is a 26 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IJO FirstGlance]. <br> | | <table><tr><td colspan='2'>[[5ijo]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJO FirstGlance]. <br> |
| </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUP155, KIAA0791 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP93, KIAA0095 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP205, C7orf14, KIAA0225 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP54 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP58, KIAA0410, NUPL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP62 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), NUP188, KIAA0169 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 21.4Å</td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ijo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijo OCA], [http://pdbe.org/5ijo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ijo RCSB], [http://www.ebi.ac.uk/pdbsum/5ijo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijo ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijo OCA], [https://pdbe.org/5ijo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijo RCSB], [https://www.ebi.ac.uk/pdbsum/5ijo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijo ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Disease == | | == Disease == |
| [[http://www.uniprot.org/uniprot/NUP62_HUMAN NUP62_HUMAN]] Familial infantile bilateral striatal necrosis. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/NU155_HUMAN NU155_HUMAN]] Familial atrial fibrillation. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/NU188_HUMAN NU188_HUMAN]] Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.<ref>PMID:21282601</ref> | | [https://www.uniprot.org/uniprot/NU188_HUMAN NU188_HUMAN] Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.<ref>PMID:21282601</ref> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/NUP62_HUMAN NUP62_HUMAN]] Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. [[http://www.uniprot.org/uniprot/NUP54_HUMAN NUP54_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. [[http://www.uniprot.org/uniprot/NU155_HUMAN NU155_HUMAN]] Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.[UniProtKB:Q99P88] [[http://www.uniprot.org/uniprot/NU205_HUMAN NU205_HUMAN]] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.<ref>PMID:15229283</ref> [[http://www.uniprot.org/uniprot/NU188_HUMAN NU188_HUMAN]] May function as a component of the nuclear pore complex (NPC). [[http://www.uniprot.org/uniprot/NUP93_HUMAN NUP93_HUMAN]] Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC.<ref>PMID:15229283</ref> <ref>PMID:15703211</ref> [[http://www.uniprot.org/uniprot/NUP58_HUMAN NUP58_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. | | [https://www.uniprot.org/uniprot/NU188_HUMAN NU188_HUMAN] May function as a component of the nuclear pore complex (NPC). |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| ==See Also== | | ==See Also== |
| *[[Nucleoporin|Nucleoporin]] | | *[[Nucleoporin 3D structures|Nucleoporin 3D structures]] |
| == References == | | == References == |
| <references/> | | <references/> |
| __TOC__ | | __TOC__ |
| </StructureSection> | | </SX> |
| [[Category: Human]] | | [[Category: Homo sapiens]] |
| [[Category: Appen, A von]] | | [[Category: Large Structures]] |
| [[Category: Beck, M]] | | [[Category: Beck M]] |
| [[Category: Kosinski, J]] | | [[Category: Kosinski J]] |
| [[Category: Mosalaganti, S]] | | [[Category: Mosalaganti S]] |
| [[Category: Nuclear pore complex]] | | [[Category: Von Appen A]] |
| [[Category: Nucleocytoplasmic transport]]
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| [[Category: Transport protein]]
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