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==Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH==
==Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH==
<StructureSection load='5zf7' size='340' side='right' caption='[[5zf7]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='5zf7' size='340' side='right'caption='[[5zf7]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZF7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZF7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CHW:3-CHLORO-4,6-DIHYDROXY-5-[(2E,6E,8S)-8-HYDROXY-3,7-DIMETHYLNONA-2,6-DIEN-1-YL]-2-METHYLBENZALDEHYDE'>CHW</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHODH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CHW:3-CHLORO-4,6-DIHYDROXY-5-[(2E,6E,8S)-8-HYDROXY-3,7-DIMETHYLNONA-2,6-DIEN-1-YL]-2-METHYLBENZALDEHYDE'>CHW</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zf7 OCA], [https://pdbe.org/5zf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zf7 RCSB], [https://www.ebi.ac.uk/pdbsum/5zf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zf7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zf7 OCA], [http://pdbe.org/5zf7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zf7 RCSB], [http://www.ebi.ac.uk/pdbsum/5zf7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zf7 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.  
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zf7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zf7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Amalia, E]]
[[Category: Large Structures]]
[[Category: Harada, S]]
[[Category: Amalia E]]
[[Category: Inaoka, K D]]
[[Category: Harada S]]
[[Category: Kido, Y]]
[[Category: Inaoka KD]]
[[Category: Kita, K]]
[[Category: Kido Y]]
[[Category: Miyazaki, Y]]
[[Category: Kita K]]
[[Category: Moore, L A]]
[[Category: Miyazaki Y]]
[[Category: Nakamura, M]]
[[Category: Moore LA]]
[[Category: Saimoto, H]]
[[Category: Nakamura M]]
[[Category: Sakai, C]]
[[Category: Saimoto H]]
[[Category: Shiba, T]]
[[Category: Sakai C]]
[[Category: Dihydroorotate/orotate]]
[[Category: Shiba T]]
[[Category: Inhibitor complex]]
[[Category: Mitochondrial inner membrane]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
[[Category: Ubiquinone/ubiquinol]]
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